It’s long been known that the proteins that package DNA — like students at a high school dance — require a chaperone. But what exactly that guardian looks and acts like has been a mystery — until now. A team of researchers at the University of Colorado Boulder has cracked the puzzle of the ‘Facilitates Chromatin Transcription’ (or FACT) protein structure. This protein is partly responsible for making sure everything goes smoothly and no improper interactions take place when DNA temporarily sheds and replaces its guardian proteins, or histones. These findings, which are the result of a project five years in the making at CU Boulder and out today in the journal Nature, will have ripple effects for not only our understanding of the genome and gene transcription, but for our understanding of cancer and the development of anti-cancer drugs. “This is just the start for this protein. It’s not the end,” said Yang Liu, a research associate at CU Boulder and one of the study’s lead authors….
Source: class=”bbc_link” target=”_blank” rel=”noopener noreferrer”>Researchers discover mysterious protein central to the functioning of DNA